About the Company
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $40 billion. Our mission is to enable our customers to make the world healthier, cleaner, and safer. We help our customers accelerate research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, and Patheon – we offer an unmatched combination of innovative technologies, purchasing convenience and pharmaceutical services. In Fresno, our facilities contribute significantly to our analytical and diagnostic product lines, supporting various life science and healthcare initiatives.
Job Description
We are seeking a highly motivated and experienced Senior Analytical Scientist with a strong focus on method development to join our dynamic R&D team in Fresno, CA. In this critical role, you will be responsible for designing, developing, optimizing, and validating analytical methods for the characterization of complex biological and chemical products, including small molecules, biologics, and novel therapeutics. You will play a pivotal role in supporting drug discovery, development, and manufacturing processes by providing robust and reliable analytical solutions. This position requires a deep understanding of various analytical techniques, strong problem-solving skills, and a commitment to quality and innovation. The successful candidate will work collaboratively with cross-functional teams, contribute to project goals, and mentor junior scientists.
Key Responsibilities
- Lead the development, optimization, and validation of novel analytical methods using techniques such as HPLC, GC, LC-MS, GC-MS, Spectroscopy (UV-Vis, IR, NMR), CE, and GPC.
- Design and execute experiments for method development, ensuring scientific rigor and data integrity.
- Perform complex data analysis, interpret results, and generate comprehensive reports for internal and external stakeholders.
- Troubleshoot and resolve analytical method performance issues, instrument malfunctions, and sample-related challenges.
- Author and review technical documents, including method development reports, validation protocols, and standard operating procedures (SOPs).
- Collaborate effectively with formulation scientists, process development engineers, quality control, and manufacturing teams to ensure seamless method transfer and implementation.
- Stay abreast of new analytical technologies and industry best practices, proposing innovative solutions to enhance analytical capabilities.
- Mentor and provide technical guidance to junior analytical scientists.
- Ensure all work is conducted in compliance with relevant regulatory guidelines (e.g., cGMP, ICH) and company policies.
Required Skills
- PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related scientific field with 5+ years of relevant industry experience; OR Master's degree with 8+ years; OR Bachelor's degree with 10+ years.
- Extensive hands-on experience in developing and validating analytical methods for pharmaceutical or biopharmaceutical products.
- Proficiency with a wide range of analytical instrumentation, particularly HPLC, GC, and mass spectrometry (LC-MS, GC-MS).
- Strong understanding of ICH guidelines (Q2(R1)) for method validation.
- Demonstrated ability to design experiments (DoE) and statistical analysis for method development and optimization.
- Excellent problem-solving skills and a proactive approach to troubleshooting.
- Strong written and verbal communication skills, with the ability to present complex scientific data clearly and concisely.
- Ability to work both independently and collaboratively in a fast-paced, multidisciplinary environment.
Preferred Qualifications
- Experience with biologics characterization techniques (e.g., CE-SDS, iCIEF, SEC-MALS).
- Familiarity with LIMS (Laboratory Information Management System) and other data management software.
- Experience in a cGMP regulated environment.
- Track record of scientific publications or presentations.
- Supervisory or team leadership experience.
Perks & Benefits
- Comprehensive Medical, Dental, and Vision insurance plans.
- Generous Paid Time Off (PTO) and company holidays.
- 401(k) retirement plan with company match.
- Life and Disability insurance.
- Employee Stock Purchase Plan (ESPP).
- Tuition reimbursement and professional development opportunities.
- On-site fitness center and wellness programs.
- Employee assistance program.
- Opportunities for career advancement within a global organization.
How to Apply
If you are interested in this position, please click the "Apply Now" button below. To ensure your application is properly considered, please prepare the following:
- An up-to-date Resume or CV
- A brief cover letter summarizing your experience and motivation
Applications are reviewed on a rolling basis. Only shortlisted candidates will be contacted for an interview.
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